The 2021–22 Northwestern Wildcats women's basketball team represented Northwestern University during the 2021–22 NCAA Division I women's basketball season. The Wildcats were led by 14th-year head coach Joe McKeown. They played their home games at Welsh–Ryan Arena as members of the Big Ten Conference. They finished the season 17–12, 8–8 in Big Ten play to finish in seventh place. They received a bye into the Second Round of the where they defeated Minnesota before losing to eventual champions Iowa in the Quarterfinals. They were not invited to the NCAA tournament or the WNIT.