The Minnesota Golden Gophers represented the University of Minnesota in WCHA women's ice hockey during the 2021-22 NCAA Division I women's ice hockey season. They won the WCHA regular-season title, but lost to Ohio State 3–2 in the conference tournament finals on home ice. After the conference tournament, the Gophers were selected as an at-large bid for the NCAA Tournament, gaining the second seed overall, behind Ohio State. They lost to the University of Minnesota–Duluth Bulldogs 2–1 at Ridder Arena in the NCAA Tournament Quarterfinals.