The 2021–22 Martyr's Memorial A-Division League (Nepali: शहीद स्मारक ए डिभिजन लिग २०७८), also known as the Qatar Airways Martyr's Memorial A-Division League for sponsorship reasons, was the 44th edition of the Martyr's Memorial A-Division League since its establishment in 1954/55. A total of 14 teams competed in the league. Machhindra F.C. were the defending champions. Due to time constraints, instead of the league winner, Machhindra F.C., the top team after matchday 7, will represent the league in the 2022 AFC Cup Preliminary Round 1.