The 2021–22 Marshall Thundering Herd men's basketball team represented Marshall University during the 2021–22 NCAA Division I men's basketball season. The Thundering Herd, led by eighth-year head coach Dan D'Antoni, played their home games at the Cam Henderson Center as members of Conference USA. They finished the season 12–21, 4–14 in C-USA play to finish in seventh place in the East Division. They defeated FIU before losing to Louisiana Tech in the second round of the C-USA tournament.