The 2021-22 Malian Première Division was the 55th season of the highest level of professional football in Mali. The championship was contested by 18 teams, starting in November 2021 and finishing in July 2022. Stade Malien were the holders going into the season following their 23nd title in the 2020-21 season, but lost the title to Djoliba AC, who won their 23rd title and drew level with Stade Malien in overall championships won.