The 2021–22 Louisville Cardinals men's basketball team represented the University of Louisville during the 2021–22 NCAA Division I men's basketball season. The team played its home games on Denny Crum Court at the KFC Yum! Center in downtown Louisville, Kentucky as members of the Atlantic Coast Conference. They were led by interim head coach Mike Pegues. The Cardinals finished the season 13–19 overall and 6–14 in ACC play to finish in a three way tie for eleventh place. As the eleventh seed in the ACC tournament, they defeated fourteenth seed Georgia Tech in the First Round before losing to sixth seed Virginia in the Second Round.