The 2021–22 Kansas State Wildcats women's basketball team represented Kansas State University in the 2021–22 NCAA Division I women's basketball season. The Wildcats were led by eighth-year head coach Jeff Mittie. They played their home games at Bramlage Coliseum in Manhattan, Kansas and were members of the Big 12 Conference. On January 23, 2022 against Oklahoma, junior Ayoka Lee set an NCAA women's basketball record of 61 points in a single game, breaking the previous record of 60 points.