The 2021–22 Florida State Seminoles women's basketball team, variously Florida State or FSU, represented Florida State University during the 2021–22 NCAA Division I women's basketball season. They were led by twenty-fourth-year head coach Sue Semrau, who returned after taking a season-long break and retired following the season. The Seminoles played their home games at the Donald L. Tucker Center on the university's Tallahassee, Florida campus. They competed as members of the Atlantic Coast Conference.