The 2021–22 First Women's Basketball League of Serbia (Serbian Cyrillic: Прва женска лига Србије 2021–22.) will be the 16th season of the First Women's Basketball League of Serbia, the highest professional basketball league in Serbia. Also, it will be the 78th national championship played by Serbian clubs inclusive of the nation's previous incarnations as Yugoslavia, Serbia and Montenegro. Crvena zvezda Kombank is the defending champion.