The 2021–22 Dayton Flyers women's basketball team represent the University of Dayton during the 2021–22 NCAA Division I women's basketball season. The Flyers, led by third-year head coach Shauna Green, play their home games at UD Arena and are members of the Atlantic 10 Conference. They finished the season 25–5, 14–1 to win the regular season championship. They advanced to the finals of the A-10 women's tournament where they lost to UMass. They received an at-large bid to the 2022 NCAA Division I women's basketball tournament.