The 2021–22 3. Liga was the 14th season of the 3. Liga. It was originally scheduled to start on 23 July 2021 and concluded on 14 May 2022; however, the opening match between VfL Osnabrück and MSV Duisburg had to be postponed after Duisburg was quarantined due to COVID-19 cases, delaying the season start by one day. From this season onward, the German Football Association will allow clubs to place a sponsor logo on the back of their shirts. The league fixtures were announced on 1 July 2021.