The 2020 Cook Out Southern 500, the 64th running of the event, was a NASCAR Cup Series race held on September 6, 2020 at Darlington Raceway in Darlington, South Carolina. Contested over 367 laps on the 1.366-mile (2.198 km) egg-shaped oval, it was the 27th race of the 2020 NASCAR Cup Series season, first race of the Playoffs, and the first race of the Round of 16. It was the first time Darlington hosted three Cup Series races in a single season.