The 2020–21 Winthrop Eagles men's basketball team represented Winthrop University in the 2020–21 NCAA Division I men's basketball season. The Eagles, led by 9th-year head coach Pat Kelsey, will play their home games at the Winthrop Coliseum in Rock Hill, South Carolina as members of the Big South Conference. They finished the season 23-2, 17-1 in Big South Play to finish as regular season champions. They defeated High Point, Longwood, and Campbell to be champions of the Big South tournament. They received the Big South’s automatic bid to the NCAA tournament where they lost in the first round to Villanova.