The 2020–21 Sydney Sixers Women's season was the sixth in the team's history. Coached by Ben Sawyer and captained by Ellyse Perry, the Sixers played the entirety of WBBL|06 in a bio-secure Sydney hub due to the COVID-19 pandemic. They finished the regular season in fifth place on the , directly below the Perth Scorchers due to an inferior net run rate. Consequently, the Sixers narrowly missed out on qualifying for the finals for the second-straight year.