The 2020–21 Purdue Boilermakers women's basketball team represented Purdue University during the 2020–21 NCAA Division I women's basketball season. The Boilermakers, led by 15th year head coach Sharon Versyp, played their home games at Mackey Arena and were a members of the Big Ten Conference. They finished the season 7–16 and 4–14 in Big Ten play to finish in twelfth place. As the eleventh seed in the Big Ten tournament, they were defeated by Iowa in the Second Round. They were not invited to the NCAA tournament or the WNIT.