The 2020–21 North Florida Ospreys men's basketball team represented the University of North Florida in the 2020–21 NCAA Division I men's basketball season. The Ospreys, led by 12th-year head coach Matthew Driscoll, played their home games at the UNF Arena in Jacksonville, Florida as members of the Atlantic Sun Conference. They finished the season 8-15, 6-6 in ASUN Play to finish in 4th place. They lost in the quarterfinals of the ASUN tournament to North Alabama.