The 2020–21 Nedbank Cup is the 2020–21 edition of South Africa's premier knockout club football (soccer) competition, the Nedbank Cup. As a result of the suspension of amateur football due to the COVID-19 pandemic, unlike in previous years, no amateur teams took part. Instead, all 16 Premier Soccer League (PSL) clubs and all 16 National First Division (NFD) teams entered the main draw of 32 teams, in spite of eight NFD teams losing their earlier first round matches.