The 2020–21 Macedonian First League was the 29th season of the Macedonian First Football League, the highest football league of North Macedonia. It began on 8 August 2020 and ended on 16 May 2021. Vardar are the defending champions, having won their eleventh title in 2019–20 after was season abandoned due to the COVID-19 pandemic. They was the third defending champions to be relegated as defending champions.