The 2019 Northern Iowa Panthers football team represented the University of Northern Iowa in the 2019 NCAA Division I FCS football season. The team was led by Mark Farley in his 19th season and played their home games in the UNI-Dome in Cedar Falls, Iowa as a member of the Missouri Valley Football Conference. They finished the season 10–5, 6–2 in MVFC play to finish in second place. They received an at-large bid to the FCS Playoffs where they defeated San Diego and South Dakota State to advance to the quarterfinals where they lost to James Madison.