The 2018–19 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2018–19 NCAA Division I women's basketball season. The Lady Eagles, led by fifteenth year head coach , played their home games at Reed Green Coliseum and were members of Conference USA. They finished the season 18–14, 9–7 in C-USA play to finish in a tie for seventh place. They lost in the first round of the C-USA women's tournament to North Texas. They received an invitation to the WBI where they defeated Nicholls in the first round before losing to North Alabama in the quarterfinals.