The 2018–19 Southern Illinois Salukis men's basketball team represented Southern Illinois University Carbondale during the 2018–19 NCAA Division I men's basketball season. The Salukis, led by seventh-year head coach Barry Hinson, played their home games at the SIU Arena in Carbondale, Illinois as members of the Missouri Valley Conference. They finished the season 17–15 overall, 10–8 in MVC play, finishing in a tie for third place. As the No. 3 seed in the MVC tournament, the Salukis were upset by No. 6 seed Northern Iowa in the quarterfinals.