The 2018–19 season is F.C. Motagua's 72nd season in existence and the club's 53rd consecutive season in the top fight of Honduran football. As runners-up of both Apertura and Clausura last season, the club is looking for their 16th and 17th league title. They also competed for the 2018 Honduran Cup and the 2018 CONCACAF League.