The 2018–19 Canisius Golden Griffins men's basketball team represented Canisius College in the 2018–19 NCAA Division I men's basketball season. They played their home games at the Koessler Athletic Center in Buffalo, New York as members of the Metro Atlantic Athletic Conference, and were led by 3rd-year head coach Reggie Witherspoon. They finished the 2018–19 season 15–17 overall, 11–7 in MAAC play to finish in a four-way tie for second place. As the No. 2 seed in the 2019 MAAC tournament, they defeated No. 7 seed Manhattan in the quarterfinals 69–65OT before falling to No. 6 seed Monmouth 59–73 in the semifinals.