The 2017 Howard Bison football team represented Howard University in the 2017 NCAA Division I FCS football season. They were led by first-year head coach Mike London. The Bison played their home games at William H. Greene Stadium. They were a member of the Mid-Eastern Athletic Conference (MEAC). The Bison kicked off the season by defeating UNLV, a 45-point favorite, in the biggest upset in college football history by point spread. They would finish the season 7–4, 6–2 in MEAC play to finish in a tie for second place.