The 2016 Ole Miss Rebels football team represented the University of Mississippi in the 2016 NCAA Division I FBS football season. The Rebels played their home games at the newly renovated Vaught–Hemingway Stadium in Oxford, Mississippi and competed in the Western Division of the Southeastern Conference (SEC). They were led by fifth-year head coach Hugh Freeze in what would turn out to be his final season with the Rebels. They finished the season 5–7, 2–6 in SEC play to finish in last place in the Western Division.