The 2015 Buffalo Bulls football team represented the University at Buffalo as a member of the East Division of the Mid-American Conference (MAC) during the 2015 NCAA Division I FBS football season. Led by first-year head coach Lance Leipold, the Bulls compiled an overall record of 5–7 with a mark of 3–5 in conference play, placing fourth in the MAC's East Division. The team played their home games at University at Buffalo Stadium in Amherst, New York.