The 2015–16 San Francisco Dons men's basketball team represented the University of San Francisco during the 2015–16 NCAA Division I men's basketball season. It was head coach Rex Walters eighth season at San Francisco. The Dons played their home games at the War Memorial Gymnasium and were members of the West Coast Conference. They finished the season 15–15, 8–10 in WCC play to finish in fifth place. They lost in the quarterfinals of the WCC tournament to Pepperdine.