The 2015–16 SMU Mustangs men's basketball team represented Southern Methodist University (SMU) during the 2015–16 NCAA Division I men's basketball season. The Mustangs were led by fourth year head coach Larry Brown and played their home games on their campus in University Park, Texas at Moody Coliseum. They were members of the American Athletic Conference. The Mustangs finished the season with a record of 25–5, 13–5 in AAC play to finish in second place in conference.