The 2012 Indiana State Sycamores football team represented Indiana State University as a member of the Missouri Valley Football Conference (MVFC) during the 2012 NCAA Division I FCS football season. Led by Trent Miles in his fifth and final season as head coach, the Sycamores compiled an overall record of 7–4 with a mark of 5–3 in conference play, placing in a three-way tie for third in the MVFC. Indiana State played home games at Memorial Stadium in Terre Haute, Indiana.