The 2010 United States House of Representatives election in South Dakota took place on Tuesday, November 2, 2010. Voters selected a representative for their single At-Large district, who run on a statewide ballot. On June 8, 2010, the Republicans nominated Kristi Noem, Assistant Majority Leader of the South Dakota House of Representatives and the Democrats nominated the incumbent Stephanie Herseth Sandlin. In the general election, Noem defeated Herseth Sandlin, winning 48.1 percent of the vote to 45.9 percent for Herseth Sandlin.