The 2010 Iowa State Cyclones football team represented Iowa State University in the 2010 NCAA Division I FBS football season. The team was led by second year head coach Paul Rhoads and played their home games at Jack Trice Stadium in Ames, Iowa. They are members of the Big 12 Conference in the North Division. They finished the season 5–7, 3–5 in Big 12 play and failed to become bowl eligible.