The 2010–11 Xavier Musketeers men's basketball team represented Xavier University in the 2010–11 college basketball season. This was head coach Chris Mack's second season at Xavier. The Musketeers competed in the Atlantic 10 Conference and played their home games at the Cintas Center. They finished the season 24–8, 15–1 in A-10 play to win the regular season conference championship. The Musketeers lost in the quarterfinals of the A-10 tournament to Dayton. They received an at-large bid in the NCAA tournament as a #6 seed where they lost in the second round to Marquette.