The 2009–10 Creighton Bluejays men's basketball team represented Creighton University in the 2009–10 NCAA Division I men's basketball season. Led by head coach Dana Altman in his 16th and subsequently final season as he would take the job at Oregon following the season. Creighton would then hire Greg McDermott as his successor. In 2009–10, the Bluejays would end the regular season with a record of 16–15 and despite losing in the first round of the Missouri Valley Conference tournament, they would qualify for the CIT and make their way to the semifinal round before losing to eventual champion Missouri State.