The 2008 UAB Blazers football team represented the University of Alabama at Birmingham (UAB) in the 2008 NCAA Division I FBS football season. The Blazers' head coach was Neil Callaway, who entered his second year at UAB. They played their home games at Legion Field in Birmingham, Alabama and competed in the East Division of Conference USA (C-USA). They improved upon a 2–10 record from the 2007 season and finished the 2008 campaign with an overall record of 4–8 (3–5 C-USA).