The 2008 SMU Mustangs football team represented Southern Methodist University (SMU) as a member the West Division of Conference USA (C-USA) during the 2008 NCAA Division I FBS football season. Led by first-year head coach June Jones, the Mustangs compiled an overall record of 1–11 with a mark of 0–8 in conference play, placing last of out of six teams in C-USA's West Division. SMU played their home games at Gerald J. Ford Stadium in University Park, Texas.