The 2005–06 Virginia Tech Hokies men's basketball team represented Virginia Polytechnic Institute and State University during the 2005–06 NCAA Division I men's basketball season. The Hokies were led by third-year head coach Seth Greenberg and played their home games at Cassell Coliseum in Blacksburg, Virginia as second-year members of the Atlantic Coast Conference. They finished the season 14–16, 4–12 in ACC play to finish a tie for tenth place. As the No. 10 seed in the ACC tournament, they were defeated in the first round by Virginia 56–60.