The 2001 San Francisco 49ers season was the franchise's 56th season and 52nd in the National Football League. The 49ers rebounded from two losing seasons in 1999 and 2000, achieving their first winning season under quarterback Jeff Garcia and returning to the playoffs behind a strong 12–4 record. However, the 49ers failed to progress further, falling 25–15 to the Green Bay Packers in the wild-card round. This was the fourth time out of five games that they had lost to the Packers in the playoffs since the 1995 season.