The 2000 Big 12 Conference football season represented the 5th season of Big 12 conference football, taking place during the 2000 NCAA Division I-A football season. The season began with non-conference play on Saturday, August 26, 2000. Conference play began on Saturday, September 30, 2000. At the conclusion of the regular season, Kansas State won the North Division championship with a 11–3 (6–2) record. Oklahoma finished atop the South Division standings, with a perfect regular season 11–0 (8–0).