The 1988 Cal State Fullerton Titans football team represented California State University, Fullerton as a member of the Big West Conference during the 1988 NCAA Division I-A football season. Led by ninth-year head coach Gene Murphy, Cal State Fullerton compiled an overall record of 5–6 with a mark of 5–2 in conference play, placing second in the Big West. The Titans played their home games at Santa Ana Stadium in Santa Ana, California.