The 1965 San Jose State Spartans football team represented San Jose State College during the 1965 NCAA University Division football season. San Jose State played as an Independent in 1965. The team was led by first-year head coach Harry Anderson, and played home games at Spartan Stadium in San Jose, California. The Spartans finished the 1965 season with a record of five wins and five losses (5–5). Overall, the team was outscored by its opponents 184–192 for the season.