The 1951 Southern 500, the second running of the event, was a NASCAR Grand National Series event that was held on September 3, 1951, at Darlington Raceway in Darlington, South Carolina. The winner of the race was Herb Thomas. The event had the most starters in NASCAR history with 82 cars starting the race, of which 58 cars would not finish the race and only one car (driven by Herb Thomas) finished on the lead lap.