The 1949 Hardin–Simmons Cowboys football team was an American football team that represented Hardin–Simmons University in the Border Conference during the 1949 college football season. In its sixth season under head coach Warren B. Woodson, the team compiled a 6–4–1 record (4–2 against conference opponents), tied for third place in the conference, and outscored opponents by a total of 318 to 189.