The 1946 South Carolina Gamecocks football team was an American football team that represented the University of South Carolina as a member of the Southern Conference (SoCon) during the 1946 college football season. In their sixth season under head coach Rex Enright, the Gamecocks compiled an overall record of 5–3 with a mark of 4–2 in conference play, placing fourth in the SoCon. The team was outscored by a total of 133 to 107 on the season.