The 1940 Birmingham Edgbaston by-election was a parliamentary by-election held for the British House of Commons constituency of Birmingham Edgbaston on 18 December 1940. The seat had become vacant when Neville Chamberlain, the constituency's Conservative Party Member of Parliament had died from stomach cancer on 9 November. Chamberlain had been Prime Minister until May 1940, and had held the Edgbaston seat since the 1929 general election.