The 1920 Middleton and Prestwich by-election was a by-election held on 22 November 1920 for the British House of Commons constituency of Middleton and Prestwich in Lancashire. The by-election was triggered by the appointment as a judge of the sitting Coalition Liberal Member of Parliament, Sir Ryland Adkins KC. Adkins was appointed Recorder of Birmingham and this being an office of profit he was obliged by the electoral law of the day to submit to a by-election.