The 1915 Ohio State Buckeyes football team represented Ohio State University as a member of the Western Conference and the Ohio Athletic Conference (OAC) during the 1915 college football season. Led by third-year head coach, John Wilce, the Buckeyes compiled an overall record of 5–1–1 and outscored opponents 105–39. Ohio State had a record of 2–1–1 against Western Conference opponents and 3–0 in OAC play.