The 1899 Kentucky State College Blue and White football team represented Kentucky State College—now known as the University of Kentucky—as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1899 college football season. Led by W. R. Bass in his second and final season as head coach, the Blue and White compiled an overall record of 5–2–2 with a mark of 0–1 in SIAA play.