16S rRNA (adenine1408-N1)-methyltransferase (EC 2.1.1.180, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine1408-N1)-methyltransferase. This enzyme catalyses the following chemical reaction S-adenosyl-L-methionine + adenine1408 in 16S rRNA S-adenosyl-L-homocysteine + N1-1408 in 16S rRNA The enzyme provides a resistance through interference with the binding of aminoglycosides.
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