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In enzymology, a 12alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) is an enzyme that catalyzes the chemical reaction 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + NADP+ 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+ Thus, the two substrates of this enzyme are and NADP+, whereas its 3 products are , NADPH, and H+.

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  • 12alpha-hydroxysteroid dehydrogenase (en)
  • 12alfa-idrossisteroide deidrogenasi (it)
  • 12α-ヒドロキシステロイドデヒドロゲナーゼ (ja)
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  • La 12alfa-idrossisteroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 3α,7α,12α-triidrossi-5β- + NADP+ ⇄ 3α,7α-diidrossi-12-osso-5β-colanato + NADPH + H+ L'enzima catalizza l'ossidazione del gruppo 12α-ossidrile degli acidi biliari, sia nella loro forma libera che in quella coniugata. L'enzima può agire anche sugli alcoli presenti nella bile. (it)
  • 12α-ヒドロキシステロイドデヒドロゲナーゼ（12α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。 3α,7α,12α-トリヒドロキシ-5β-コラン酸 + NADP+ 3α,7α-ジヒドロキシ-12-オキソ-5β-コラン酸 + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はとNADPHとH+である。 組織名は12α-hydroxysteroid:NADP+ 12-oxidoreductaseで、別名に12α-hydroxy steroid dehydrogenase, 12α-hydroxy steroid dehydrogenase, NAD+-dependent 12α-hydroxysteroid dehydrogenase, NADP+-12α-hydroxysteroid dehydrogenaseがある。 (ja)
  • In enzymology, a 12alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) is an enzyme that catalyzes the chemical reaction 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + NADP+ 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+ Thus, the two substrates of this enzyme are and NADP+, whereas its 3 products are , NADPH, and H+. (en)
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  • 12-alpha-hydroxysteroid dehydrogenase (en)
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  • In enzymology, a 12alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) is an enzyme that catalyzes the chemical reaction 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + NADP+ 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+ Thus, the two substrates of this enzyme are and NADP+, whereas its 3 products are , NADPH, and H+. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 12alpha-hydroxysteroid:NADP+ 12-oxidoreductase. Other names in common use include 12alpha-hydroxy steroid dehydrogenase, 12alpha-hydroxy steroid dehydrogenase, NAD+-dependent 12alpha-hydroxysteroid dehydrogenase, and NADP+-12alpha-hydroxysteroid dehydrogenase. This enzyme is involved in a metabolic pathway that degrades bile acids into cholesterol. (en)
  • La 12alfa-idrossisteroide deidrogenasi è un enzima appartenente alla classe delle ossidoreduttasi, che catalizza la seguente reazione: 3α,7α,12α-triidrossi-5β- + NADP+ ⇄ 3α,7α-diidrossi-12-osso-5β-colanato + NADPH + H+ L'enzima catalizza l'ossidazione del gruppo 12α-ossidrile degli acidi biliari, sia nella loro forma libera che in quella coniugata. L'enzima può agire anche sugli alcoli presenti nella bile. (it)
  • 12α-ヒドロキシステロイドデヒドロゲナーゼ（12α-hydroxysteroid dehydrogenase）は、次の化学反応を触媒する酸化還元酵素である。 3α,7α,12α-トリヒドロキシ-5β-コラン酸 + NADP+ 3α,7α-ジヒドロキシ-12-オキソ-5β-コラン酸 + NADPH + H+ 反応式の通り、この酵素の基質はとNADP+、生成物はとNADPHとH+である。 組織名は12α-hydroxysteroid:NADP+ 12-oxidoreductaseで、別名に12α-hydroxy steroid dehydrogenase, 12α-hydroxy steroid dehydrogenase, NAD+-dependent 12α-hydroxysteroid dehydrogenase, NADP+-12α-hydroxysteroid dehydrogenaseがある。 (ja)
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  • 1.1.1.176
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