Seth Irunsewe Kale MBE, OON, CFR (June 6, 1904 – November 19, 1994) was a Nigerian Anglican bishop who served as Principal of CMS Grammar School, Lagos from 1944 to 1950 and as Bishop of Lagos from 1963 to 1974. He was consecrated a bishop on St Andrew's Day (30 November) 1963, by Cecil Patterson, Archbishop of West Africa. He holds the distinction of being the first African to preach in the famous St Paul's Cathedral, London.